NU227326 - CAS 3048196-52-4

NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon) .

PROTACs, IDO, Indoleamine 2,3-Dioxygenase (IDO)

Metabolism, PROTAC

3048140

C53H61FN8O7

941.099

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=C(C2)N4CCN(CC4)C5CCN(CC(=O)N6CCC(OC7=CC(NC([C@H](C)[C@]8(CC[C@H](CC8)C=9C%10=C(N=CC9)C=CC(F)=C%10)[H])=O)=CC=C7)CC6)CC5

-20°C

Ice Packs

PROTAC