Nur77 modulator 3 - CAS 2097787-75-0

Nur77 modulator 3 (9e) binds to Nur77 and inhibits TGF-β1-induced α-SMA and COLA1 expression in a Nur77-dependent manner. It induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis [1].

Autophagy, mTOR

Autophagy, PI3K/Akt/mTOR signaling

2097787-75-0

C17H16N4S

308.4

C(=N/NC(NC1=CC=C(C)C=C1)=S)\C=2C=3C(NC2)=CC=CC3

-20°C

Ice Packs

Small Compound