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Molfinity

Nutlin-3 - CAS 548472-68-0

Nutlin-3 - CAS 548472-68-0

MF-0018588-01

$40.65 USD
$40.65 USD
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Product Details

  • Bioactivity

    Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.

  • Target

    E1/E2/E3 Enzyme, MDM-2/p53

  • Related Pathways

    Apoptosis, Ubiquitination

  • CAS Number

    548404

  • Purity

    0.9989

  • Molecular Formula

    C30H30Cl2N4O4

  • Molecular Weight

    581.49

  • SMILES

    COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound