Nutlin-3a - CAS 675576-98-4

Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.

Apoptosis, E1/E2/E3 Enzyme, Autophagy, MDM-2/p53

Autophagy, Apoptosis, Ubiquitination

675474

0.9971

C30H30Cl2N4O4

581.49

COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

-20°C

Ice Packs

Small Compound