NVP-BQS481 - CAS 1161925-41-2

NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs) .

Others, Kinesin

Cytoskeletal Signaling, Others

1161882

C27H33F3N4O2

502.57

[C@@H](N(CC[C@@H](CF)N)C(CO)=O)(C(C)(C)C)C=1N(CC2=CC=CC=C2)C=C(N1)C3=C(F)C=CC(F)=C3

-20°C

Ice Packs

Small Compound