NVP-QBE170 - CAS 1080018-61-6

NVP-QBE170 is a selective epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. It effectively suppresses ENaC function in human bronchial epithelial cells (HBEC), with a prolonged duration of action. NVP-QBE170 significantly decreases ENaC activity in guinea pig airway models and can be utilized for hyperkalemia research.

Sodium Channel

Membrane transporter/Ion channel

1079951

C30H36Cl2N16O4

755.62

O=C(NC(=N)NC1CCN(C(=O)C2=CC=C(C=C2)C(=O)N3CCC(NC(=N)NC(=O)C4=NC(Cl)=C(N=C4N)N)CC3)CC1)C5=NC(Cl)=C(N=C5N)N

-20°C

Ice Packs

Small Compound