NVR3-778 hydrate - CAS 2093094-04-1

NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV) -infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 μM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos (t) ide inhibitors of HBV replication.

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Others

2093094-04-1

C18H18F4N2O5S

450.4

O.OC1CCN(CC1)S(=O)(=O)c1cc(ccc1F)C(=O)Nc1cc(F)c(F)c(F)c1

-20°C

Ice Packs

Small Compound