NX-5948 - CAS 2649400-34-8

NX-5948 (BTK-IN-24) is an orally bioavailable and blood-brain barrier-penetrable PROTAC BTK degrader with anti-inflammatory and antitumor activities. It induces BTK protein degradation via the cereblon E3 ligase complex, inhibiting B cell activation.

PROTACs, BTK

PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis

2649358

0.9829

C42H54N12O5

806.96

N(C=1N=C(C=NC1C(N)=O)N2C[C@@H](CCC2)N3C(=O)N(C)CC3)C4=CC=C(C=C4)C5CCN(CC6CCN(CC6)C=7C=CC(C(N[C@@H]8C(=O)NC(=O)CC8)=O)=NC7)CC5

-20°C

Ice Packs

PROTAC