NZ-66 - CAS 3062992-25-7

NZ-66 is a chimeric molecule that targets UNC-51-like kinase 1 (ULK1) to facilitate proximity-induced, ULK1-dependent mitochondrial degradation. It triggers mitophagy (mitochondrial autophagy) and has potential for alleviating neurodegenerative diseases.

Mitophagy, Autophagy

Autophagy

3062960

C48H40F8N8O5

960.87

C(C(NCCCCCCN1C=C(COC2=CC=C([C@H](C(NC3=C(F)C=C(F)C=C3)=O)NC(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)C=C2)N=N1)=O)(=O)C5=C(NC=6C5=CC=CC6)C7=CC=CC=C7

-20°C

Ice Packs

Small Compound