NZ-804 - CAS 2858658-44-1

NZ-804 is an orally active inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 8.9 nM. It inhibits replication of SARS-CoV-2 in HeLa-hACE2 cells, showing an EC50 of 14 nM. NZ-804 exhibits broad-spectrum antiviral activity against various CoVs and decreases viral replication in mice and hamster models.

SARS-CoV, Virus Protease

Microbiology/Virology

2858613

C27H23N3O3S

469.56

O=C(C1=CN=CC=2C=CNC21)N3CCC(=C4C=5C=CC=CC5CS(=O)(=O)C=6C=CC=CC64)CC3

-20°C

Ice Packs

Small Compound