O-Demethyl Apremilast - CAS 1384441-38-6

O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively) . O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3

Others

Others

1384397

C21H22N2O7S

446.47

CCOc1cc(ccc1O)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O

-20°C

Ice Packs

Small Compound