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O-Desmethyl gefitinib - CAS 847949-49-9

O-Desmethyl gefitinib - CAS 847949-49-9

MF-0015989-01

$48.12 USD
$48.12 USD
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Product Details

  • Bioactivity

    O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays) . In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

  • Target

    EGFR

  • Related Pathways

    Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

  • CAS Number

    847891

  • Purity

    0.996

  • Molecular Formula

    C21H22ClFN4O3

  • Molecular Weight

    432.88

  • SMILES

    Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound