O-Desmethylcarvedilol - CAS 72956-44-6

O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 μM) . Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 μg/kg) .

Calcium Channel

Membrane transporter/Ion channel, Metabolism

72906

C23H24N2O4

392.45

OC=1C=CC=CC1OCCNCC(O)COC2=CC=CC=3NC=4C=CC=CC4C23

-20°C

Ice Packs

Small Compound