OATD-02 - CAS 2146132-73-0

OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and Arginase2, exhibiting inhibitory concentrations (IC50) of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1) . Notably, OATD-02 mitigates tumor immunosuppression provoked by these arginases and has potential application in melanoma research [1].

Arginase

Immunology/Inflammation

2146059

C12H25BN2O4

272.15

C(O)(=O)[C@]1(N)[C@H](CN(C)C)CC[C@@H](CCB(O)O)C1

-20°C

Ice Packs

Small Compound