OD36 hydrochloride - CAS 2387510-88-3

OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.

ALK, TGF-beta/Smad, RIP kinase

NF-κB, Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors, Apoptosis

2387419

0.9985

C16H16Cl2N4O2

367.23

Cl.ClC=1C=C2OCCOCCN=C3C=CN4N=CC(C(C1)=C2)=C4N3

-20°C

Ice Packs

Small Compound