Oltipraz - CAS 64224-21-1

Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD (P) H: quinone oxidoreductase 1 (NQO1) . The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

Nrf2, Parasite, Reverse Transcriptase, HIF/HIF Prolyl-Hydroxylase, HIV Protease, HIF

Proteases/Proteasome, Immunology/Inflammation, Chromatin/Epigenetic, Metabolism, Microbiology/Virology, Angiogenesis

64202

>99.99%

C8H6N2S3

226.34

CC1=C(SSC1=S)C1=NC=CN=C1

-20°C

Ice Packs

Small Compound