Onatasertib - CAS 1228013-30-6

Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Onatasertib is a potent mTOR kinase inhibitor (IC50: 16 nM), with >150-fold sensitivity than the related lipid kinase PI3Kα (IC50: 4 μM) .

Apoptosis, DNA-PK, FLT, mTOR, c-Fms, PI3K

Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling, Apoptosis, DNA Damage/DNA Repair

1227977

0.9993

C21H27N5O3

397.47

CO[C@H]1CC[C@@H](CC1)N1C(=O)CNc2ncc(nc12)-c1ccc(nc1)C(C)(C)O

-20°C

Ice Packs

Small Compound