ONO-2920632 - CAS 2230296-66-7

ONO-2920632 is an orally active and CNS-penetrant TREK channel activator with EC50 values of 0.3 μM for TREK-1 and 2.8 μM for TREK-2. It demonstrates selectivity for other K2P channels, showing over 91-fold selectivity against TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selectivity against TRESK. ONO-2920632 exhibits analgesic effects and is used in the study of pain, migraine, and neurological disorders.

Potassium Channel

Membrane transporter/Ion channel

2230223

C15H10F4N4O2

354.259

O=C(NCC1=CC=C(OC(F)(F)F)C=C1F)C=2C=CC3=NC=NN3C2

-20°C

Ice Packs

Small Compound