ONO-7579 - CAS 1622212-25-2

ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.

Trk receptor

Tyrosine Kinase/Adaptors

1622185

C24H18ClF3N6O4S

578.95

O=C(NC1=CN=C(N=C1)OC=2C=CC(=CC2)C3=CC(Cl)=CN=C3N)NC4=CC(=CC=C4S(=O)(=O)C)C(F)(F)F

-20°C

Ice Packs

Small Compound