Ontunisertib - CAS 2647949-48-0

Ontunisertib (Example 26) is a TGFβ receptor I/ALK5 (TGFβRI/ALK5) inhibitor with an IC50 value range of 100-500 nM for TGFβRI and an IC50 value of ≤100 nM for ALK5. This compound is applicable for research in gastrointestinal diseases, fibrosis-related conditions of the skin and eyes, and cancer.

TGF-beta/Smad

Stem Cells

2647901

C27H21F2N5O

469.485

O=C(NCC=1C(F)=CC=CC1F)CN2N=C(C=3N=C(C=CC3)C)C(=C2)C=4C=CN=C5C=CC=CC54

-20°C

Ice Packs

Small Compound