Opaganib HCl - CAS 1185157-59-8

ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2.

Others, S1P Receptor

Others, GPCR/G Protein

1185090

C23H26Cl2N2O

417.37

C(NCC=1C=CN=CC1)(=O)C23CC4(CC(C2)CC(C4)C3)C5=CC=C(Cl)C=C5.Cl

-20°C

Ice Packs

Small Compound