OPB-3206 - CAS 166245-54-1

OPB-3206 is a selective inhibitor of matrix metalloproteinases (MMPs) . It inhibits stromelysin, collagenase, gelatinase A (MMP-2), and gelatinase B (MMP-9) with IC50 values of 7x10^-7 M, 5x10^-6 M, 5x10^-7 M, and 2x10^-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding site of MMPs, blocking the activation of MMP-9 and reducing the degradation of the extracellular matrix, thereby inhibiting tumor lung metastasis. OPB-3206 shows potential for research in osteosarcoma lung metastasis.

MMP

Proteases/Proteasome

166190

C18H25N3O5

363.41

O(C)N1C=2C(C[C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C1=O)=CC=CC2

-20°C

Ice Packs

Small Compound