Org 274179-0 - CAS 1421683-12-6

Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI) -mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD) .

TSH Receptor

GPCR/G Protein

1421665

C28H27F3N2O2

480.521

C[C@@]1(C=2C(N(C(C)=O)CC1)=CC=C(NC(CCC3=CC(C(F)(F)F)=CC=C3)=O)C2)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound