Oritinib mesylate - CAS 2180164-79-6

Oritinib mesylate (SH-1028) is a highly selective, orally active, pyrimidine-based irreversible inhibitor of epidermal growth factor receptor (EGFR) with a low IC50 of 18 nM. It is effective against both EGFR-sensitive and resistant (T790M) mutations and suppresses the proliferation of tumor cells harboring EGFR mutations, irrespective of their sensitivity or resistance.

EGFR, Others

Others, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

2180079

C32H41N7O5S

635.78

CS(O)(=O)=O.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1c2CCCCn2c2ccccc12

-20°C

Ice Packs

Small Compound