OSI-027 - CAS 936890-98-1

OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.

MTOR, Autophagy, DNA-PK, PI3K

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Autophagy

936791

0.98

C21H22N6O3

406.44

COc1cccc2=C\C(N=c12)=c1/nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12

-20°C

Ice Packs

Small Compound