OSI-296 - CAS 1175296-94-2

OSI-296 is a potent and dual inhibitor of cMET and RON kinases (IC50 value are 42 nM and 200 nM for cMet and sfRon respectively) . OSI-206 shows in vivo efficacy and is well tolerated in tumor xenografts models upon oral dosing. OSI-296 also reduces tumour growth in the bone.

C-Met/HGFR, Others

Tyrosine Kinase/Adaptors, Others

1175200

C21H19Cl2FN4O3

465.3

O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=C3C(C(=CO3)C=4CCN(C(N)=O)CC4)=CN=C2N

-20°C

Ice Packs

Small Compound