Osunprotafib - CAS 2489404-97-7

Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]

STAT, JAK, Phosphatase

Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Stem Cells, JAK/STAT signaling, Metabolism

2489404-97-7

>99.99%

C17H24FN3O4S

385.45

CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1

-20°C

Ice Packs

Small Compound