Osunprotafib hydrochloride - CAS 2986745-48-4

Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM) . It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.

Phosphatase

Metabolism

2986693

C17H25ClFN3O4S

421.92

FC=1C(=C(O)C=C2C1C[C@H](NCCC(C)C)CC2)N3CC(=O)NS3(=O)=O.Cl

-20°C

Ice Packs

Small Compound