Oxaprozin potassium - CAS 174064-08-5

Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. It induces cell apoptosis and inhibits NF-κB activation. The inhibition of the Akt/IKK/NF-κB pathway by oxaprozin potassium contributes to its anti-inflammatory properties [1] [2].

IκB/IKK, Apoptosis, NF-κB, Akt, COX, Others

NF-κB, Cytoskeletal Signaling, Apoptosis, Immunology/Inflammation, Neuroscience, PI3K/Akt/mTOR signaling, Others

174064-08-5

C18H14KNO3

331.412

[K+].[O-]C(=O)CCc1nc(c(o1)-c1ccccc1)-c1ccccc1

-20°C

Ice Packs

Small Compound