Oxatomide - CAS 60607-34-3

Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2X7 receptor with an IC50 value of 0.95 μM.Oxatomide has an inhibitory effect on ATP-induced Ca2+ inward currents with an IC50 value of 0.43 μM.Oxatomide inhibits 5-hydroxytryptamine. Oxatomide inhibits 5-hydroxytryptamine with an IC50 of 0.43 μM.Oxatomide is used in the treatment of immune system diseases and in the study of hypersensitivity reactions.

P2X Receptor, p38 MAPK, Histamine Receptor, Calcium Channel, 5-HT Receptor, Apoptosis, COX, PERK

Metabolism, Apoptosis, GPCR/G Protein, Neuroscience, Membrane transporter/Ion channel, Immunology/Inflammation, MAPK

60570

0.9972

C27H30N4O

426.55

O=C1NC2=C(C=CC=C2)N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1

-20°C

Ice Packs

Small Compound