P-gp-IN-30 - CAS 2761881-65-4

P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC) .

P-gp

Neuroscience, Membrane transporter/Ion channel

2761812

C34H36N2O9

616.66

C(OCC)(=O)C1(C(OCC)=O)[C@@]2([C@@H]([C@H](N1)C=3[C@@]4([C@](CC3)(C(C(OC)=O)=CO[C@H]4OC)[H])[H])C5=CC=CC=C5)C=6C(NC2=O)=CC=CC6

-20°C

Ice Packs

Small Compound