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P-gp inhibitor 14 - CAS 2892571-47-8

P-gp inhibitor 14 - CAS 2892571-47-8

MF-0147711-01

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Product Details

  • Bioactivity

    Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM) . Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].

  • Target

    P-gp

  • Related Pathways

    Membrane transporter/Ion channel, Neuroscience

  • CAS Number

    2892571-47-8

  • Molecular Formula

    C37H38N2O8

  • Molecular Weight

    638.71

  • SMILES

    O(C)C=1C2=C(C=3C=4C5=C(C(OC)=CC4CN(CC3C1)C6=CC=C(CCN7CC=8C(CC7)=CC(OC)=C(OC)C8)C=C6)OCO5)OCO2

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound