P-nitro-Pifithrin-α - CAS 389850-21-9

P-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

TGF-beta/Smad, Others, Caspase, MDM-2/p53

Others, Stem Cells, Proteases/Proteasome, Apoptosis

389820

C15H16BrN3O3S

398.27

Br.[O-][N+](=O)c1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N

-20°C

Ice Packs

Small Compound