P162-0948 - CAS 1358201-44-1

P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.

CDK

Cell Cycle/Checkpoint

1358156

C20H15FN4O2

362.357

O=C(NCC1=CC=C(F)C=C1)CC2=NN=C(O2)C=3C=CC=4N=CC=CC4C3

-20°C

Ice Packs

Small Compound