P2X3 antagonist 34 - CAS 2417288-67-4

P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It shows reduced activity against P2X2/3 heterotrimeric receptors across human, rat, and guinea pig models. Notably, this compound demonstrates a significant anti-tussive effect without altering taste[1].

P2X Receptor

Neuroscience, Membrane transporter/Ion channel

2417217

C24H26F2N4O3

456.48

CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@@H]2CCCN(C2)C(=O)OC)c(F)c1

-20°C

Ice Packs

Small Compound