P2X3 antagonist 38 - CAS 2545974-71-6

Compound 38, also known as Compound 4, is a potent, orally active P2X3 antagonist that demonstrates inhibitory activity with IC50 values of 0.132 μM, 0.165 μM, and 0.421 μM against human (hP2X3), rat (rP2X3), and guinea pig (gpP2X3) P2X3 receptors, respectively [1].

P2X Receptor

Neuroscience, Membrane transporter/Ion channel

2545897

C22H25F3N6O3

478.47

N(C(OCC)=O)(C)[C@@H]1C(=NN(C(N[C@H](C)C=2C=NC(C(F)(F)F)=NC2)=O)C1)C3=CC=C(C)C=C3

-20°C

Ice Packs

Small Compound