P2Y14R antagonist 4 - CAS 3081687-67-1

Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) induced by LPS.

P2Y Receptor, Interleukin

Immunology/Inflammation, Neuroscience, GPCR/G Protein

3081619

C27H27F3N2O4S

532.574

O=C(O)C1=CC(=CC(=C1)C2=CC=C(C=C2)C3CCNCC3)NS(=O)(=O)CCC4=CC=C(C=C4)C(F)(F)F

-20°C

Ice Packs

Small Compound