P38 MAP Kinase Inhibitor IV - CAS 1638-41-1

P38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.

Others, p38 MAPK

MAPK, Others

1596

C12H4Cl6O4S

456.94

Oc1c(Cl)cc(Cl)c(Cl)c1S(=O)(=O)c1c(O)c(Cl)cc(Cl)c1Cl

-20°C

Ice Packs

Small Compound