P53-MDM2-IN-6 - CAS 1054506-59-0

P53-MDM2-IN-6, an LSM-83177 hydrazone analog, acts as an efficacious p53-MDM2 inhibitor with an IC50 of 11.08 μg/mL. This compound inhibits the p53-MDM2 interaction leading to an increase in p-53 levels while concurrently decreasing GST enzyme expression. It halts the cell cycle at the S phase and induces early and late apoptosis (Apoptosis), exhibiting antiproliferative activity against the HT29 cell line with an IC50 of 10.44 μg/mL. p53-MDM2-IN-6 holds promise for research in colorectal cancer.

MDM-2/p53, Apoptosis

Apoptosis

1054447

C17H17N3O4

327.33

O=C(O)COC1=CC=C(C=NNC(=O)CNC=2C=CC=CC2)C=C1

-20°C

Ice Packs

Small Compound