P53 Stabilizer 2 - CAS 2531685-87-5

P53 Stabilizer 2 (Compound 17a16) is a p53 stabilizing agent. It can induce S-phase arrest and apoptosis in both p53-functional and p53-deficient cancer cells. Additionally, p53 Stabilizer 2 triggers mitochondrial stress and activates two immune checkpoint pathways: NA-PKcs dependent p53 stabilization and the ATR-Chk1 axis activation. It also inhibits tumor growth in p53-deficient xenograft models.

MDM-2/p53, Apoptosis, Chk

Cell Cycle/Checkpoint, Apoptosis

2531593

C30H37NO7Se

602.58

O(C)C=1C=2[C@@](N(C)CCC2C(C[Se]C3CCCCCC3)=C4C1OCO4)([C@@]5(C=6C(C(=O)O5)=C(OC)C(OC)=CC6)[H])[H]

-20°C

Ice Packs

Small Compound