P7C3 - CAS 301353-96-8

The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI) . This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage.

Others

Others

301249

0.996

C21H18Br2N2O

474.19

OC(CNc1ccccc1)Cn1c2ccc(Br)cc2c2cc(Br)ccc12

-20°C

Ice Packs

Small Compound