PA-8 - CAS 878437-15-1

PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.

PACAP

GPCR/G Protein

878421

0.9764

C17H18N4O4

342.35

COc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12

-20°C

Ice Packs

Small Compound