PAD4-IN-5 - CAS 3071873-52-1

PAD4-IN-5 (Example 18) is a PAD4 inhibitor with an IC50 of ≤10 nM at 50 μM Ca2+ and 101-500 nM at 1 mM Ca2+ against human PAD4 (hPAD4) . This compound is applicable in the study of autoimmune diseases such as rheumatoid arthritis (RA) .

PAD

Chromatin/Epigenetic

3071820

C34H41N7O3

595.734

CN1C(C=2N3C=4C(C2)=CC=C(N4)[C@@H](C)NC(=O)[C@]5([C@](CCCCC3)(C5)[H])[H])=NC=6C1=CC7=C(C6)C(=O)N(C[C@H]8COCCN8)CC7

-20°C

Ice Packs

Small Compound