Pan-HER-IN-1 - CAS 1639040-94-0

Pan-HER-IN-1 (Compound C5) is an irreversible, orally active Pan-HER inhibitor that exhibits IC50 values of 0.38 nM for EGFR, 1.6 nM for HER4, 2.2 nM for EGFR T790M/L858R, and 3.5 nM for HER2, respectively. pan-HER-IN-1 induces apoptosis and demonstrates antitumor activities.

EGFR, Apoptosis, Others

Others, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

1638946

C19H14BrN5O

408.25

N(C=1C2=C(C=CC(NC(C=C)=O)=C2)N=CN1)C=3C=C4C(=CC3)NC=C4Br

-20°C

Ice Packs

Small Compound