Pan-HER-IN-2 - CAS 1639040-95-1

Pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that targets EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50: 8.2 nM), and L858R (IC50: 75.1 nM) . pan-HER-IN-2 induces apoptosis and possesses anti-tumor effects.

Others, Apoptosis, EGFR

Others, JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis

1638944

C19H15BrClN5O

444.71

N(C=1C2=C(C=CC(NC(CCCl)=O)=C2)N=CN1)C=3C=C4C(=CC3)NC=C4Br

-20°C

Ice Packs

Small Compound