Pan-KRAS-IN-2 - CAS 2882825-14-9

Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].

Ras

MAPK, GPCR/G Protein

2882802

C34H34F2N4O3

584.66

C(OC=1N=C(C2=C(N1)C(C)=C(C=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CCCOCC5)[C@@]67N(C[C@H](F)C6)CCC7

-20°C

Ice Packs

Small Compound