Pan-Raf/RTK inhibitor 1 - CAS 1980821-53-1

Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf) . It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.

Raf

MAPK

1980767

C29H28F3N7O3

579.573

O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCOCC2)C3=CC=C(C(=C3)NC(=O)C4(C5=NC=NC=6N=CNC65)CC4)C

-20°C

Ice Packs

Small Compound