Panduratin A - CAS 89837-52-5

Panduratin A is a natural chalcone derivative with inhibitory activity against MMP-9 in human oral epidermoid carcinoma KB cells; inhibitory activity against the NS3 protease of DENV-2 (Ki=25 μM) ; significant cytotoxicity against human androgen-independent prostate cancer cells PC-3 and DU-145; and also able to activate the LKB1-AMPK- PPARα /δ signaling pathway and enhance the oxidative capacity of myocyte mitochondria.

AMPK, MMP, Apoptosis, PPAR, Virus Protease, Antibacterial

Microbiology/Virology, Metabolism, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, DNA Damage/DNA Repair

89837-52-5

C26H30O4

406.51

C(=O)([C@H]1[C@@H](CC=C(C)[C@H]1CC=C(C)C)C2=CC=CC=C2)C3=C(O)C=C(OC)C=C3O

-20°C

Ice Packs

Natural Product