PaPE-1 - CAS 2107327-36-4

PaPE-1 is a pathway-preferential estrogen that activates extracellular nuclear signaling pathways without affecting nuclear signaling pathways. It exerts anti-apoptotic effects by inhibiting Aβ-induced caspase activity and reducing chromatin condensation associated with apoptosis, thereby preventing neuronal cell death. Additionally, post-treatment with PaPE-1 decreases the mRNA expression of apoptosis-specific factors (such as Bax, Gsk3b, Fas, and Fasl) under Aβ influence, while upregulating Bcl2 expression.

2107287

C17H18O2

254.32

O[C@@H]1C=2C(=CC(=CC2)C3=CC(C)=C(O)C(C)=C3)CC1

-20°C

Ice Packs

Small Compound