PARP/EZH2-IN-1 - CAS 2687273-52-3

PARP/EZH2-IN-1 is a novel dual inhibitor targeting PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for treating triple-negative breast cancer with wild-type BRCA.

Others, Histone Methyltransferase, PARP

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic

2687218

C43H41FN8O5

768.85

CC(=O)Nc1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F

-20°C

Ice Packs

Small Compound